Human SP17 (SPA17) activation kit by CRISPRa

CAT#: GA110001

SPA17 CRISPRa kit - CRISPR gene activation of human sperm autoantigenic protein 17

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPA17
• Locus ID: 53340
• Kit Components:

  GA110001G1, SPA17 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110001G2, SPA17 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110001G3, SPA17 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017425
• Synonyms: CT22; SP17; SP17-1
• Summary: This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. [provided by RefSeq, Jan 2009]