Human KCNK10 activation kit by CRISPRa

CAT#: GA110074

KCNK10 CRISPRa kit - CRISPR gene activation of human potassium two pore domain channel subfamily K member 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNK10
• Locus ID: 54207
• Kit Components:

  GA110074G1, KCNK10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110074G2, KCNK10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110074G3, KCNK10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021161, NM_138317, NM_138318
• Synonyms: K2p10.1; PPP1R97; TREK-2; TREK2
• Summary: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]