Human TREM1 activation kit by CRISPRa

CAT#: GA110076

TREM1 CRISPRa kit - CRISPR gene activation of human triggering receptor expressed on myeloid cells 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TREM1
• Locus ID: 54210
• Kit Components:

  GA110076G1, TREM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110076G2, TREM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110076G3, TREM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242589, NM_001242590, NM_018643, NR_136332
• Synonyms: CD354; TREM-1
• Summary: This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]