Human DGCR8 activation kit by CRISPRa

CAT#: GA110131

DGCR8 CRISPRa kit - CRISPR gene activation of human DGCR8 microprocessor complex subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DGCR8
• Locus ID: 54487
• Kit Components:

  GA110131G1, DGCR8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110131G2, DGCR8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110131G3, DGCR8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190326, NM_022720
• Synonyms: C22orf12; DGCRK6; Gy1; pasha
• Summary: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]