Human MTRF1L activation kit by CRISPRa

CAT#: GA110151

MTRF1L CRISPRa kit - CRISPR gene activation of human mitochondrial translational release factor 1 like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTRF1L
• Locus ID: 54516
• Kit Components:

  GA110151G1, MTRF1L gRNA vector 1 in pCas-Guide-CRISPRa

  GA110151G2, MTRF1L gRNA vector 2 in pCas-Guide-CRISPRa

  GA110151G3, MTRF1L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114184, NM_001301047, NM_001301870, NM_001301871, NM_001301872, NM_019041, NR_126056
• Synonyms: HMRF1L; MRF1L; mtRF1a
• Summary: The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]