Human KLHL24 activation kit by CRISPRa

CAT#: GA110269

KLHL24 CRISPRa kit - CRISPR gene activation of human kelch like family member 24

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLHL24
• Locus ID: 54800
• Kit Components:

  GA110269G1, KLHL24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110269G2, KLHL24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110269G3, KLHL24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017644, NM_001349413, NM_001349414, NM_001349415, NM_001349416, NM_001349417, NM_001349418, NM_001349419, NM_001349420, NM_001349421, NM_001349422, NM_001349423, NM_001349424, NM_001349425, NM_001349426, NM_001349427, NM_001349428, NM_001349429, NR_146169, NR_146170
• Synonyms: DRE1; KRIP6
• Summary: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]