Human NDE1 activation kit by CRISPRa

CAT#: GA110285

NDE1 CRISPRa kit - CRISPR gene activation of human nudE neurodevelopment protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NDE1
• Locus ID: 54820
• Kit Components:

  GA110285G1, NDE1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110285G2, NDE1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110285G3, NDE1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143979, NM_017668
• Synonyms: HOM-TES-87; LIS4; MHAC; NDE; NUDE; NUDE1
• Summary: This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]