Human Asporin (ASPN) activation kit by CRISPRa

CAT#: GA110293

ASPN CRISPRa kit - CRISPR gene activation of human asporin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ASPN
• Locus ID: 54829
• Kit Components:

  GA110293G1, ASPN gRNA vector 1 in pCas-Guide-CRISPRa

  GA110293G2, ASPN gRNA vector 2 in pCas-Guide-CRISPRa

  GA110293G3, ASPN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193335, NM_017680
• Synonyms: OS3; PLAP-1; PLAP1; SLRR1C
• Summary: This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]