Human CLN6 activation kit by CRISPRa

CAT#: GA110426

CLN6 CRISPRa kit - CRISPR gene activation of human CLN6 transmembrane ER protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLN6
• Locus ID: 54982
• Kit Components:

  GA110426G1, CLN6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110426G2, CLN6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110426G3, CLN6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017882
• Synonyms: CLN4A; HsT18960; nclf
• Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]