Human TRMT12 activation kit by CRISPRa

CAT#: GA110474

TRMT12 CRISPRa kit - CRISPR gene activation of human tRNA methyltransferase 12 homolog

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRMT12
• Locus ID: 55039
• Kit Components:

  GA110474G1, TRMT12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110474G2, TRMT12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110474G3, TRMT12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017956
• Synonyms: TRM12; TYW2
• Summary: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006). [supplied by OMIM, Mar 2008]