Human HIPPI (IFT57) activation kit by CRISPRa

CAT#: GA110500

IFT57 CRISPRa kit - CRISPR gene activation of human intraflagellar transport 57

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFT57
• Locus ID: 55081
• Kit Components:

  GA110500G1, IFT57 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110500G2, IFT57 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110500G3, IFT57 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018010
• Synonyms: ESRRBL1; HIPPI; MHS4R2
• Summary: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. [UniProtKB/Swiss-Prot Function]