Human MSL2L1 (MSL2) activation kit by CRISPRa

CAT#: GA110569

MSL2 CRISPRa kit - CRISPR gene activation of human MSL complex subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MSL2
• Locus ID: 55167
• Kit Components:

  GA110569G1, MSL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110569G2, MSL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110569G3, MSL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145417, NM_018133
• Synonyms: MSL-2; MSL2L1; RNF184
• Summary: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProtKB/Swiss-Prot Function]