Human TMLHE activation kit by CRISPRa

CAT#: GA110615

TMLHE CRISPRa kit - CRISPR gene activation of human trimethyllysine hydroxylase, epsilon

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMLHE
• Locus ID: 55217
• Kit Components:

  GA110615G1, TMLHE gRNA vector 1 in pCas-Guide-CRISPRa

  GA110615G2, TMLHE gRNA vector 2 in pCas-Guide-CRISPRa

  GA110615G3, TMLHE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184797, NM_018196
• Synonyms: AUTSX6; BBOX2; TMLD; TMLH; TMLHED; XAP130
• Summary: This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]