Human NUDT15 activation kit by CRISPRa

CAT#: GA110659

NUDT15 CRISPRa kit - CRISPR gene activation of human nudix hydrolase 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NUDT15
• Locus ID: 55270
• Kit Components:

  GA110659G1, NUDT15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110659G2, NUDT15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110659G3, NUDT15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304745, NM_018283, NR_136687, NR_136688
• Synonyms: MTH2
• Summary: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]