Human IL17B Receptor (IL17RB) activation kit by CRISPRa

CAT#: GA110783

IL17RB CRISPRa kit - CRISPR gene activation of human interleukin 17 receptor B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL17RB
• Locus ID: 55540
• Kit Components:

  GA110783G1, IL17RB gRNA vector 1 in pCas-Guide-CRISPRa

  GA110783G2, IL17RB gRNA vector 2 in pCas-Guide-CRISPRa

  GA110783G3, IL17RB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018725, NM_172234
• Synonyms: CRL4; EVI27; IL17BR; IL17RH1
• Summary: The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]