Human OTUB1 activation kit by CRISPRa

CAT#: GA110821

OTUB1 CRISPRa kit - CRISPR gene activation of human OTU deubiquitinase, ubiquitin aldehyde binding 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OTUB1
• Locus ID: 55611
• Kit Components:

  GA110821G1, OTUB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110821G2, OTUB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110821G3, OTUB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017670, NR_003089
• Synonyms: HSPC263; OTB1; OTU1
• Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]