Human TRM1 (TRMT1) activation kit by CRISPRa

CAT#: GA110830

TRMT1 CRISPRa kit - CRISPR gene activation of human tRNA methyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRMT1
• Locus ID: 55621
• Kit Components:

  GA110830G1, TRMT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110830G2, TRMT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110830G3, TRMT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136035, NM_001142554, NM_017722, NM_001351760, NM_001351761, NM_001351762
• Synonyms: TRM1
• Summary: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]