Human NALP2 (NLRP2) activation kit by CRISPRa

CAT#: GA110857

NLRP2 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NLRP2
• Locus ID: 55655
• Kit Components:

  GA110857G1, NLRP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110857G2, NLRP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110857G3, NLRP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001174081, NM_001174082, NM_001174083, NM_017852, NM_001348003, NR_145325
• Synonyms: CLR19.9; NALP2; NBS1; PAN1; PYPAF2
• Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]