Human TRMT1 (TRMU) activation kit by CRISPRa

CAT#: GA110883

TRMU CRISPRa kit - CRISPR gene activation of human tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRMU
• Locus ID: 55687
• Kit Components:

  GA110883G1, TRMU gRNA vector 1 in pCas-Guide-CRISPRa

  GA110883G2, TRMU gRNA vector 2 in pCas-Guide-CRISPRa

  GA110883G3, TRMU gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001008568, NM_001008569, NM_001008570, NM_001008571, NM_001282782, NM_001282783, NM_001282784, NM_001282785, NM_018006, NR_104240, NR_104241
• Synonyms: MGC99627; MTO2; MTU1; TRMT; TRMT1
• Summary: This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]