Human PACS1 activation kit by CRISPRa

CAT#: GA110885

PACS1 CRISPRa kit - CRISPR gene activation of human phosphofurin acidic cluster sorting protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PACS1
• Locus ID: 55690
• Kit Components:

  GA110885G1, PACS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110885G2, PACS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110885G3, PACS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018026, NM_178178
• Synonyms: MRD17
• Summary: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]