Human VAC14 activation kit by CRISPRa

CAT#: GA110891

VAC14 CRISPRa kit - CRISPR gene activation of human VAC14 component of PIKFYVE complex

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VAC14
• Locus ID: 55697
• Kit Components:

  GA110891G1, VAC14 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110891G2, VAC14 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110891G3, VAC14 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018052, NM_001351157
• Synonyms: ArPIKfyve; TAX1BP2; TRX
• Summary: This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017]