Human POLR3B activation kit by CRISPRa

CAT#: GA110897

POLR3B CRISPRa kit - CRISPR gene activation of human RNA polymerase III subunit B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POLR3B
• Locus ID: 55703
• Kit Components:

  GA110897G1, POLR3B gRNA vector 1 in pCas-Guide-CRISPRa

  GA110897G2, POLR3B gRNA vector 2 in pCas-Guide-CRISPRa

  GA110897G3, POLR3B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160708, NM_018082
• Synonyms: C128; HLD8; INMAP; RPC2
• Summary: This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]