Human ARFGAP1 activation kit by CRISPRa

CAT#: GA110925

ARFGAP1 CRISPRa kit - CRISPR gene activation of human ADP ribosylation factor GTPase activating protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARFGAP1
• Locus ID: 55738
• Kit Components:

  GA110925G1, ARFGAP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110925G2, ARFGAP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110925G3, ARFGAP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281482, NM_001281483, NM_001281484, NM_018209, NM_175609, NR_104022, NR_104023
• Synonyms: ARF1GAP; HRIHFB2281
• Summary: The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]