Human TDP1 activation kit by CRISPRa

CAT#: GA110958

TDP1 CRISPRa kit - CRISPR gene activation of human tyrosyl-DNA phosphodiesterase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TDP1
• Locus ID: 55775
• Kit Components:

  GA110958G1, TDP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110958G2, TDP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110958G3, TDP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001008744, NM_001330205, NM_018319
• Synonyms: FLJ11090; MGC104252
• Summary: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]