Human CACNA2D3 activation kit by CRISPRa

CAT#: GA110979

CACNA2D3 CRISPRa kit - CRISPR gene activation of human calcium voltage-gated channel auxiliary subunit alpha2delta 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CACNA2D3
• Locus ID: 55799
• Kit Components:

  GA110979G1, CACNA2D3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110979G2, CACNA2D3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110979G3, CACNA2D3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018398
• Synonyms: HSA272268
• Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]