Human VPS11 activation kit by CRISPRa

CAT#: GA110998

VPS11 CRISPRa kit - CRISPR gene activation of human VPS11 core subunit of CORVET and HOPS complexes

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPS11
• Locus ID: 55823
• Kit Components:

  GA110998G1, VPS11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110998G2, VPS11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110998G3, VPS11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001290185, NM_021729
• Synonyms: END1; hVPS11; PEP5; RNF108
• Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]