Human TIP120A (CAND1) activation kit by CRISPRa

CAT#: GA111005

CAND1 CRISPRa kit - CRISPR gene activation of human cullin associated and neddylation dissociated 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAND1
• Locus ID: 55832
• Kit Components:

  GA111005G1, CAND1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111005G2, CAND1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111005G3, CAND1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018448, NM_001329674, NM_001329675, NM_001329676
• Synonyms: TIP120; TIP120A
• Summary: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]