Human PEN2 (PSENEN) activation kit by CRISPRa

CAT#: GA111019

PSENEN CRISPRa kit - CRISPR gene activation of human presenilin enhancer, gamma-secretase subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PSENEN
• Locus ID: 55851
• Kit Components:

  GA111019G1, PSENEN gRNA vector 1 in pCas-Guide-CRISPRa

  GA111019G2, PSENEN gRNA vector 2 in pCas-Guide-CRISPRa

  GA111019G3, PSENEN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281532, NM_018468, NM_172341
• Synonyms: MDS033; MSTP064; PEN-2; PEN2
• Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]