Human ANKH activation kit by CRISPRa

CAT#: GA111152

ANKH CRISPRa kit - CRISPR gene activation of human ANKH inorganic pyrophosphate transport regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ANKH
• Locus ID: 56172
• Kit Components:

  GA111152G1, ANKH gRNA vector 1 in pCas-Guide-CRISPRa

  GA111152G2, ANKH gRNA vector 2 in pCas-Guide-CRISPRa

  GA111152G3, ANKH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_019847, NM_054027
• Synonyms: ANK; CCAL2; CMDJ; CPPDD; HANK; MANK
• Summary: This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]