Human Cytochrome P450 26B (CYP26B1) activation kit by CRISPRa

CAT#: GA111196

CYP26B1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 26 subfamily B member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP26B1
• Locus ID: 56603
• Kit Components:

  GA111196G1, CYP26B1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111196G2, CYP26B1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111196G3, CYP26B1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277742, NM_019885
• Synonyms: CYP26A2; P450RAI-2; P450RAI2; RHFCA
• Summary: This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]