Human DIABLO activation kit by CRISPRa

CAT#: GA111199

DIABLO CRISPRa kit - CRISPR gene activation of human diablo IAP-binding mitochondrial protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DIABLO
• Locus ID: 56616
• Kit Components:

  GA111199G1, DIABLO gRNA vector 1 in pCas-Guide-CRISPRa

  GA111199G2, DIABLO gRNA vector 2 in pCas-Guide-CRISPRa

  GA111199G3, DIABLO gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278302, NM_001278303, NM_001278304, NM_001278342, NM_019887, NM_138929, NM_138930, NR_024600, NR_024601, N66735
• Synonyms: DFNA64; SMAC
• Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]