Human SPHK2 activation kit by CRISPRa

CAT#: GA111232

SPHK2 CRISPRa kit - CRISPR gene activation of human sphingosine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPHK2
• Locus ID: 56848
• Kit Components:

  GA111232G1, SPHK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111232G2, SPHK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111232G3, SPHK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204158, NM_001204159, NM_001204160, NM_001243876, NM_020126
• Synonyms: SK-2; SK 2; SPK-2; SPK 2
• Summary: This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]