Human RAD18 activation kit by CRISPRa

CAT#: GA111236

RAD18 CRISPRa kit - CRISPR gene activation of human RAD18 E3 ubiquitin protein ligase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD18
• Locus ID: 56852
• Kit Components:

  GA111236G1, RAD18 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111236G2, RAD18 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111236G3, RAD18 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020165
• Synonyms: RNF73
• Summary: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]