Human ARNTL2 activation kit by CRISPRa

CAT#: GA111285

ARNTL2 CRISPRa kit - CRISPR gene activation of human aryl hydrocarbon receptor nuclear translocator like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARNTL2
• Locus ID: 56938
• Kit Components:

  GA111285G1, ARNTL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111285G2, ARNTL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111285G3, ARNTL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001248002, NM_001248003, NM_001248004, NM_001248005, NM_020183
• Synonyms: bHLHe6; BMAL2; CLIF; MOP9; PASD9
• Summary: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]