Human TIGAR activation kit by CRISPRa

CAT#: GA111372

TIGAR CRISPRa kit - CRISPR gene activation of human TP53 induced glycolysis regulatory phosphatase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIGAR
• Locus ID: 57103
• Kit Components:

  GA111372G1, TIGAR gRNA vector 1 in pCas-Guide-CRISPRa

  GA111372G2, TIGAR gRNA vector 2 in pCas-Guide-CRISPRa

  GA111372G3, TIGAR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020375
• Synonyms: C12orf5; FR2BP
• Summary: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]