Human Nogo A (RTN4) activation kit by CRISPRa

CAT#: GA111402

RTN4 CRISPRa kit - CRISPR gene activation of human reticulon 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RTN4
• Locus ID: 57142
• Kit Components:

  GA111402G1, RTN4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111402G2, RTN4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111402G3, RTN4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007008, NM_020532, NM_153828, NM_207520, NM_207521, NM_001321859, NM_001321860, NM_001321861, NM_001321862, NM_001321863, NM_001321904, NR_135829, NR_135830
• Synonyms: ASY; Nbla00271; Nbla10545; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A
• Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]