Human SCYL1 activation kit by CRISPRa

CAT#: GA111487

SCYL1 CRISPRa kit - CRISPR gene activation of human SCY1 like pseudokinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCYL1
• Locus ID: 57410
• Kit Components:

  GA111487G1, SCYL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111487G2, SCYL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111487G3, SCYL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001048218, NM_020680
• Synonyms: GKLP; HT019; NKTL; NTKL; P105; TAPK; TEIF; TRAP
• Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]