Human KCC2 (SLC12A5) activation kit by CRISPRa

CAT#: GA111513

SLC12A5 CRISPRa kit - CRISPR gene activation of human solute carrier family 12 member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC12A5
• Locus ID: 57468
• Kit Components:

  GA111513G1, SLC12A5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111513G2, SLC12A5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111513G3, SLC12A5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134771, NM_020708
• Synonyms: EIEE34; EIG14; hKCC2; KCC2
• Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]