Human KIDINS220 activation kit by CRISPRa

CAT#: GA111539

KIDINS220 CRISPRa kit - CRISPR gene activation of human kinase D interacting substrate 220

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KIDINS220
• Locus ID: 57498
• Kit Components:

  GA111539G1, KIDINS220 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111539G2, KIDINS220 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111539G3, KIDINS220 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020738, NM_001348729, NM_001348731, NM_001348732, NM_001348734, NM_001348735, NM_001348736, NM_001348738, NM_001348739, NM_001348740, NM_001348741, NM_001348742, NM_001348743, NM_001348745, NR_145964, NR_145965
• Synonyms: ARMS
• Summary: This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]