Human MRTFA activation kit by CRISPRa

CAT#: GA111616

MRTFA CRISPRa kit - CRISPR gene activation of human myocardin related transcription factor A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MRTFA
• Locus ID: 57591
• Kit Components:

  GA111616G1, MRTFA gRNA vector 1 in pCas-Guide-CRISPRa

  GA111616G2, MRTFA gRNA vector 2 in pCas-Guide-CRISPRa

  GA111616G3, MRTFA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282660, NM_001282661, NM_001282662, NM_001318139, NM_020831
• Synonyms: BSAC; MAL; MRTF-A
• Summary: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]