Human SH3MD2 (SH3RF1) activation kit by CRISPRa

CAT#: GA111646

SH3RF1 CRISPRa kit - CRISPR gene activation of human SH3 domain containing ring finger 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH3RF1
• Locus ID: 57630
• Kit Components:

  GA111646G1, SH3RF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111646G2, SH3RF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111646G3, SH3RF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020870
• Synonyms: POSH; RNF142; SH3MD2
• Summary: This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]