Human GBA3 activation kit by CRISPRa

CAT#: GA111721

GBA3 CRISPRa kit - CRISPR gene activation of human glucosylceramidase beta 3 (gene/pseudogene)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GBA3
• Locus ID: 57733
• Kit Components:

  GA111721G1, GBA3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111721G2, GBA3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111721G3, GBA3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128432, NM_001277225, NM_020973, NR_102355, NR_102356, NR_102357
• Synonyms: CBG; CBGL1; GLUC; KLRP
• Summary: The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]