Human TRIB3 activation kit by CRISPRa

CAT#: GA111723

TRIB3 CRISPRa kit - CRISPR gene activation of human tribbles pseudokinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIB3
• Locus ID: 57761
• Kit Components:

  GA111723G1, TRIB3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111723G2, TRIB3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111723G3, TRIB3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301188, NM_001301190, NM_001301193, NM_001301196, NM_001301201, NM_021158
• Synonyms: C20orf97; NIPK; SINK; SKIP3; TRB3
• Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]