Human MARK4 activation kit by CRISPRa

CAT#: GA111726

MARK4 CRISPRa kit - CRISPR gene activation of human microtubule affinity regulating kinase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARK4
• Locus ID: 57787
• Kit Components:

  GA111726G1, MARK4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111726G2, MARK4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111726G3, MARK4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199867, NM_031417
• Synonyms: MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D
• Summary: This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]