Human POLD4 activation kit by CRISPRa

CAT#: GA111732

POLD4 CRISPRa kit - CRISPR gene activation of human DNA polymerase delta 4, accessory subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POLD4
• Locus ID: 57804
• Kit Components:

  GA111732G1, POLD4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111732G2, POLD4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111732G3, POLD4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256870, NM_021173, NR_046411, NR_046412, NR_046413
• Synonyms: p12; POLDS
• Summary: This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]