Human CARD12 (NLRC4) activation kit by CRISPRa

CAT#: GA111767

NLRC4 CRISPRa kit - CRISPR gene activation of human NLR family CARD domain containing 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NLRC4
• Locus ID: 58484
• Kit Components:

  GA111767G1, NLRC4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111767G2, NLRC4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111767G3, NLRC4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199138, NM_001199139, NM_001302504, NM_021209
• Synonyms: AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF
• Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]