Human Prol1 (OPRPN) activation kit by CRISPRa

CAT#: GA111784

OPRPN CRISPRa kit - CRISPR gene activation of human opiorphin prepropeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OPRPN
• Locus ID: 58503
• Kit Components:

  GA111784G1, OPRPN gRNA vector 1 in pCas-Guide-CRISPRa

  GA111784G2, OPRPN gRNA vector 2 in pCas-Guide-CRISPRa

  GA111784G3, OPRPN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302807, NM_021225, NR_126503
• Synonyms: BPLP; opiorphin; PRL1; PROL1
• Summary: This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]