Human C3IP1 (KLHL12) activation kit by CRISPRa

CAT#: GA111833

KLHL12 CRISPRa kit - CRISPR gene activation of human kelch like family member 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLHL12
• Locus ID: 59349
• Kit Components:

  GA111833G1, KLHL12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111833G2, KLHL12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111833G3, KLHL12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303051, NM_001303109, NM_021633
• Synonyms: C3IP1; DKIR
• Summary: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]