Human SLC5A7 activation kit by CRISPRa

CAT#: GA111851

SLC5A7 CRISPRa kit - CRISPR gene activation of human solute carrier family 5 member 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC5A7
• Locus ID: 60482
• Kit Components:

  GA111851G1, SLC5A7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111851G2, SLC5A7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111851G3, SLC5A7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001305005, NM_001305006, NM_001305007, NM_021815
• Synonyms: CHT; CHT1; hCHT; HMN7A
• Summary: This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]