Human SMOC2 activation kit by CRISPRa

CAT#: GA111969

SMOC2 CRISPRa kit - CRISPR gene activation of human SPARC related modular calcium binding 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SMOC2
• Locus ID: 64094
• Kit Components:

  GA111969G1, SMOC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111969G2, SMOC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111969G3, SMOC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166412, NM_022138
• Synonyms: bA37D8.1; bA270C4A.1; dJ421D16.1; DTDP1; MST117; MSTP117; MSTP140; SMAP2
• Summary: This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]